Know Some Significant Procedures Involved In Pharmacokinetics

What is bioequivalence?

In general, the term bioequivalence is a connection between two preparations of the identical drug in a similar dosage, which have the same bioavailability. The bioequivalence is also referred to as pharmacokinetics, used to identify the movement of the drug in, through and out of your body. The pharmacokinetics is surrounded by four different processes of a medication like excretion, absorption, metabolism, and distribution.

These types of processes are influenced under the control of functioning and administration of your body organs. Now you are going to see some detailed information of these processes involved in the Bioequivalence study.

Process Involved In Bioequivalence:

Absorption:

The term the absorption is used to mention the mechanism of medication (a drug or medicine used to prevent or cure the disease) from entering into the body to the bloodstream. Generally, if any of the medications entered into the body, which is taken by your mouth and it can be effectively absorbed by your intestinal mucosa or stomach. The enteral medication in your body is in the form being like blood flow, food in the stomach and drug solubility.

The parenteral is considered as another route of absorption, from that you have to inject the medications into your body. The absorption rate will be highly varied it completely depends upon the type of injection.

Types of Injection:

  • Intravenous: The intravenous medications are injected directly into the bloodstream, which has been absorbed quickly in your body.
  • Subcutaneous: The Subcutaneous medications are injected directly into the tissue in between your muscle and skin; this is because of the large amount of blood supplied to the muscles.
  • Intramuscular: The intramuscular medications are injected inwards into the muscles, which can be absorbed quicker than the subcutaneous injection.

Distribution:

The term distribution is nothing but the transformation of medications through the bloodstream to the planned action site. The medications are generally used for curing the variety of diseases in your body. Intake of medicines completely depends upon your health issues, so you have to make a consultation with your personal doctor.  The rate of distribution of medications in your body can be determined by the blood supply to the area.

For instance, the blood supply to the area like the heart and brain become very high, so the rate of distribution will also be more. The medications can also be distributed to the areas like excretion and metabolism; because once the medication is injected, it has been distributed throughout the body.

Metabolism and Excretion:

Metabolism is nothing but the breakdown of medications tends to be in an active form. As per the bioequivalence study, the metabolism is also called as biotransformation. Initially, the medications are metabolized in the primary organ; liver and some other medications metabolism have happened in the intestinal tract, kidney, and lungs.

Thus, these are all the important processes plays an important role in the human body which taking the medications. Make use of this information, if you want to know about some information about bioequivalence.